Radioprotective agents in the treatment of cancer and the role of amifostine


SÜZEN S.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.28, sa.2, ss.117-128, 1999 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1501/eczfak_0000000336
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.117-128
  • Anahtar Kelimeler: Amifostine, Cancer, Ionising radiation, Radioprotectors
  • Ankara Üniversitesi Adresli: Evet

Özet

Recently, there has been an increase in the interest in research on radioprotective agents. The aim is to achieve preferential protection of normal tissues against injury inflicted by ionising radiation or chemotherapy agents used to treat tumours. There are several classes of radioprotective compounds are present and still under investigation. Among these agents, commonly the sulfydryl-containing amifostine (Ethyol®) is currently the most widely used. Amifostine is a potent radioprotector of normal tissues and protect against radiation carcinogenesis. To be successful in tumor therapy, developing of new radioprotective compounds is urgently needed considering the amifostine is the only one effective compound in use in cancer treatment so far.