Akademik Veri Yönetim Sistemi
Fabad Journal of Pharmaceutical Sciences, cilt.49, sa.2, ss.423-434, 2024 (Scopus)
A wound is the event of deterioration of the integrity of soft tissue. The intricate tissue restoration process during wound healing involves cellular and molecular activities. Wound healing includes three phases: hemostasis and inflammatory phase, proliferation phase, and remodeling phase. Diabetes mellitus (DM), an endocrine system disease, occurs due to the absence of insulin or resistance to the effect of insulin. Problems with angiogenesis, immunity, and risk of infection make diabetic wound care difficult. Various studies have been carried out to increase wound healing in diabetes and skin wounds, and the use of herbal products in this direction is increasing. Momordica charantia (MC) is well-known for its ability to treat diabetes and repair wounds. MC is a plant widely grown in the world and in our country. It is a used both in the pharmaceutical industry and as a nutrient. MC, a member of the Cucurbitaceae family, is the scientific name for bitter gourd. Sterols, triterpenoids, polypeptides, saponins, flavonoids, and alkaloids are present in MC. Phytochemical studies have shown that bioactive components have antidiabetic, antioxidant, antiviral, antimicrobial, anti-inflammatory, antitumor, hypolipidemic, immunomodulatory, and wound-healing activities. Studies have shown that MC extract increases epithelialization, neovascularization and fibroblast proliferation in wounds and accelerates wound healing by suppressing inflammation. It is thought that the topical application of the extract of the MC plant can accelerate wound healing in skin and diabetic wounds and help treatment.