Protective action of doxycycline against diabetic cardiomyopathy in rats

YARAŞ N., Sariahmetoglu M., BİLGİNOĞLU A., Aydemir-Koksoy A., BEŞİKCİ A., Turan B., ...Daha Fazla

BRITISH JOURNAL OF PHARMACOLOGY, cilt.155, sa.8, ss.1174-1184, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 155 Sayı: 8
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1038/bjp.2008.373
  • Dergi Adı: BRITISH JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1174-1184
  • Anahtar Kelimeler: metalloproteinases, diabetes mellitus, cardiomyopathy, calcium, calcium sparks, electrophysiology, ISCHEMIA-REPERFUSION INJURY, MATRIX METALLOPROTEINASE-2 EXPRESSION, ACUTE MYOCARDIAL-ISCHEMIA, RYANODINE RECEPTOR, POLY(ADP-RIBOSE) POLYMERASE, VENTRICULAR MYOCYTES, CARDIAC DYSFUNCTION, OXIDATIVE STRESS, TISSUE INHIBITOR, HEART
  • Ankara Üniversitesi Adresli: Evet

Özet

Background and purpose: Reactive oxygen and nitrogen species play an important role in the development of diabetic cardiomyopathy. They can activate matrix metalloproteinases (MMPs), and MMP-2 in particular is known to mediate early consequences of oxidative stress injury in the heart. Therefore, we investigated the role of MMP-2 and the effect of the MMP inhibitor doxycycline on the changes of heart function caused by diabetes.