The possible role of benzodiazepine receptors in morphine analgesia

Palaoǧlu Ö., Ayhan I.

Pharmacology, Biochemistry and Behavior, cilt.25, sa.1, ss.215-217, 1986 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 1986
  • Doi Numarası: 10.1016/0091-3057(86)90255-8
  • Dergi Adı: Pharmacology, Biochemistry and Behavior
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.215-217
  • Anahtar Kelimeler: Analgesia, Benzodiazepine receptor, Diazepam, Morphine, Ro 15-1788
  • Ankara Üniversitesi Adresli: Evet

Özet

Diazepam within its therapeutic dose range, was shown to have no effect on nociception, but was shown to antagonize the analgesic action of morphine. This antagonism was found to be statistically significant at 0.5 mg/kg diazepam. To elucidate the mechanism of this inhibitory action of diazepam against morphine analgesia, Ro 15-1788, the specific antagonist of benzodiazepine receptors was used. As a result, Ro 15-1788 was found to partially reverse the inhibitory action of diazepam against morphine analgesia. This overall interaction between the supramolecular GABA receptor complex and morphine is discussed. © 1986.