The possible role of benzodiazepine receptors in morphine analgesia

Palaoǧlu Ö., Ayhan I.

Pharmacology, Biochemistry and Behavior, vol.25, no.1, pp.215-217, 1986 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 1
  • Publication Date: 1986
  • Doi Number: 10.1016/0091-3057(86)90255-8
  • Journal Name: Pharmacology, Biochemistry and Behavior
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.215-217
  • Keywords: Analgesia, Benzodiazepine receptor, Diazepam, Morphine, Ro 15-1788
  • Ankara University Affiliated: Yes

Abstract

Diazepam within its therapeutic dose range, was shown to have no effect on nociception, but was shown to antagonize the analgesic action of morphine. This antagonism was found to be statistically significant at 0.5 mg/kg diazepam. To elucidate the mechanism of this inhibitory action of diazepam against morphine analgesia, Ro 15-1788, the specific antagonist of benzodiazepine receptors was used. As a result, Ro 15-1788 was found to partially reverse the inhibitory action of diazepam against morphine analgesia. This overall interaction between the supramolecular GABA receptor complex and morphine is discussed. © 1986.