Where have all the active receptor states gone?

ONARAN H. O., Costa T.

NATURE CHEMICAL BIOLOGY, cilt.8, sa.8, ss.674-677, 2012 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 8
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1038/nchembio.1024
  • Dergi Adı: NATURE CHEMICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.674-677
  • Ankara Üniversitesi Adresli: Evet

Özet

Defining G protein-coupled receptor ligand efficacy and biased agonism in precise chemical terms is one challenge posed by the current structural data that exists for this receptor family. Concepts classically used for understanding enzymes and other nonreceptor proteins may lead us in the right direction.