Clinical Significance of Incidental Pituitary TC-99m MIBI Uptake on Parathyroid Spect and Factors Affecting Uptake Intensity

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Araz M., Cayir D., Ucan B., Dilli A., Cakal E.

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, cilt.33, sa.7, ss.295-299, 2018 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 7
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1089/cbr.2017.2433
  • Dergi Adı: CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.295-299
  • Anahtar Kelimeler: Tc-99m MIBI, pituitary gland, incidental findings, BRAIN-TUMORS, SESTAMIBI
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: (1)To define a quantitative cutoff value for incidental pituitary Technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) uptake above which is of clinical importance and (2) to investigate possible factors affecting the intensity of uptake in pituitary adenoma. Materials and Methods: A retrospective analysis of 55 patients with a simultaneous parathyroid single-photon emission computed tomography and pituitary magnetic resonance imaging were included. Twenty-four patients with pituitary adenoma were chosen as the study group and 31/55 patients who had no signs of a pituitary adenoma were included in the control group. Mean count values (count/pixel) for pituitary region of interest (ROI)/mean value for normal cortical region ROI (P/C) were calculated in both groups. Median P/C values were compared. A cutoff value for P/C was calculated as a quantitative parameter to indicate pituitary tumors. Possible contributing factors in intensity of pituitary Tc-99m MIBI uptake were investigated. Results: Median P/C ratios were significantly higher in the study group (p<0.001). A cutoff value of 7.675 was found for P/C to have a sensitivity, spesificity, positive predictive value, and negative predictive value 100%, 96.8%, 96%, and 100%, respectively. There was no correlation between investigated factors and degree of pituitary Tc-99m MIBI uptake. Conclusions: Incidental pituitary Tc-99m MIBI uptake values above 7.675 for P/C are suspicious for pituitary adenoma and can be further investigated clinically and radiologically. Tc-99m MIBI uptake is not affected from the biochemical nature of the adenoma, the therapies received, size, local invasion, or cystic necrotic component of the tumor.