Akademik Veri Yönetim Sistemi
Türkiye Klinikleri Veteriner Bilimleri Dergisi, cilt.15, sa.1, ss.1-8, 2024 (Hakemli Dergi)
Objective: The study explores Myrtus communis L. extract (ME) as a potential antioxidant agent in drinking water. It encompassed in vitro assays and in vivo tests on Wistar albino rats.Material and Methods: ME's antioxidant activity (AOA) was evaluated using metal chelating activity (MCA), reducing power (RP), and superoxide radical scavenging activity (SRSA) assays. In vivo experiments involved exposing rat groups to various ME concentrations (0, 1.25, 2.5, 3.75 ve 5 mL/cage). Redox parameters were analyzed in blood, liver, and kidney tissues, exploring treatment, gender, and redox marker interactions. Results: MCA showed the highest AOA at 0.1 mg/mL and the lowest at 0.4 mg/mL, while RP exhibited the opposite (p<0.05). The changes in SRSA levels were not statistically significant (p>0.05). Pearson correlation unveiled a strong negative link between RP and SRSA (p<0.05). MCA and RP showed a weaker, insignificant negative correlation, while MCA and SRSA displayed a moderate, little positive correlation (p<0.05). In vivo analysis highlighted interactions among treatment, gender, and redox markers. Total oxidant status (TOS) in blood was affected by the interaction of treatment and gender. TOS exhibited dose-dependent effects in blood, while other parameters (malondialdehyde, reduced glutathione, total antioxidant status) remained unchanged primarily (p<0.05). Conclusion: ME showed concentration-dependent antioxidant effects in vitro and in vivo. Although tissue redox balance was minimally affected, kidney GSH elevation indicated potential antioxidant benefits. This underscores ME's potential as a natural health supplement, urging further investigations for optimal doses and effects. The study highlights ME's potential in the food and pharmaceutical sectors.