Expression of CYP and GST in human normal and colon tumor tissues

Bulus H., Oguztuzun S., Simsek G. G., KILIÇ M., ADA A. O., Gol S., ...Daha Fazla

BIOTECHNIC & HISTOCHEMISTRY, cilt.94, sa.1, ss.1-9, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 94 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/10520295.2018.1493220
  • Dergi Adı: BIOTECHNIC & HISTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-9
  • Anahtar Kelimeler: Adenocarcinoma, colon, cytochrome P450, glutathione-S-transferase, human, smoking status, GLUTATHIONE-S-TRANSFERASE, CYTOCHROMES P450, PI EXPRESSION, ASSOCIATION, METABOLISM, ENZYMES, CANCER
  • Ankara Üniversitesi Adresli: Evet

Özet

We investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1, and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 in colon tumor and surrounding normal colon tissues. Tissues were obtained from 47 patients with colon adenocarcinoma and the staining intensity of tumor and control tissues was compared. CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTT1, GSTO1 and GSTK1 expressions in colon cancer cells were significantly greater than those in normal colon epithelial cells. No significant relation was found between the isoenzyme expressions and age, gender, smoking status, tumor grade and tumor stage. The higher expressions of CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTO1, GSTT1 and GSTK1 in tumor than in normal colon tissues may be important for colon cancer progression and development.