The ultrastructure of the capillaries in the gingiva of alloxan-induced diabetic rats

GÜL N., Ozsoy N.

CELL BIOCHEMISTRY AND FUNCTION, cilt.21, sa.4, ss.311-315, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1002/cbf.1033
  • Dergi Adı: CELL BIOCHEMISTRY AND FUNCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.311-315
  • Anahtar Kelimeler: diabetes mellitus (alloxan-induced), ultrastructure, capillary, gingiva, connective tissue, MELLITUS, DISEASE, TISSUE, TYPE-1, MODEL
  • Ankara Üniversitesi Adresli: Evet

Özet

The diabetic effects of alloxan (type I diabetes mellitus) were investigated in 40 Wistar albino rats (18 controls and 22 diabetics). Alloxan in sterile physiological saline was injected into animals intravenously. After the induction of diabetes with alloxan, the ultrastructure of the capillaries in the gingiva was examined by transmission electron microscopy. The thickness of the basement membranes was observed closely adherent to the endothelial cells of the capillary alloxan-diabetic rats. It was greatly thickened owing to the increase in its amorphous, granular and filamentous material with occasional scattered collagen fibres. In some sections, the capillary lumens of the diabetics were closed by epithelial cells. Loss of cytoplasmic material and hyalinization were seen in some smooth muscle cells. In addition, the mitochondrial cristae of smooth muscle cell and epithelial cells disappeared. There was endothelial integrity throughout the smooth muscle cells. Copyright (C) 2003 John Wiley Sons, Ltd.