MTHFR 677C -> T polymorphism and risk of coronary heart disease - A meta-analysis

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Klerk M., Verhoef P., Clarke R., Blom H., Kok F., Schouten E.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, cilt.288, sa.16, ss.2023-2031, 2002 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Derleme
• Cilt numarası: 288 Sayı: 16
• Basım Tarihi: 2002
• Doi Numarası: 10.1001/jama.288.16.2023
• Dergi Adı: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.2023-2031
• Ankara Üniversitesi Adresli: Evet

Özet

Context In observational studies, individuals with elevated levels of plasma homocysteine tend to have moderately increased risk of coronary heart disease (CHD). The MTHFR 677C-->T polymorphism is a genetic alteration in an enzyme involved in folate metabolism that causes elevated homocysteine concentrations, but its relevance to risk of CHD is uncertain.