Neutrophilic Alveolitis and High Serum Pro-Brain Natriuretic Peptide Level may be Indicators of Pulmonary Functional Impairment in Connective Tissue Disorders
ARCHIVES OF RHEUMATOLOGY, sa.1, ss.14-23, 2016 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2016
- Doi Numarası: 10.5606/archrheumatol.2016.5720
- Dergi Adı: ARCHIVES OF RHEUMATOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.14-23
- Anahtar Kelimeler: Bronchoalveolar lavage, collagen tissue disorder, pro-brain natriuretic peptide, pulmonary arterial hypertension, six-minute walking test, INTERSTITIAL LUNG-DISEASE, HIGH-RESOLUTION CT, SYSTEMIC-SCLEROSIS, ARTERIAL-HYPERTENSION, RHEUMATOID-ARTHRITIS, SJOGRENS-SYNDROME, REVISED CRITERIA, SMALL AIRWAYS, RISK-FACTORS, CLASSIFICATION
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Üniversitesi Adresli: Evet
Özet
Objectives: This study aims to assess the role of several diagnostic tests and tools, immune markers, and the association between serum pro-brain natriuretic peptide levels and other parameters in patients with collagen tissue disorders with pulmonary involvement. Patients and methods: In this prospective study, 62 patients (17 males, 45 females; mean age 58.1 +/- 13.6 years; range 24 to 87 years) with pulmonary involvement of connective tissue disorders were evaluated using several functional parameters (six-minute walking test, serum pro-brain natriuretic peptide, echocardiographic measurement of the pulmonary pressure, respiratory functional parameters, and blood pressure measurement), bronchoalveolar lavage differential cytology and/or flow cytometric analysis. Results: Duration of disease was 7.6 years. Diagnoses included rheumatoid arthritis (38.7%), scleroderma (38.7%), primary Sjogren's syndrome (16.1%), mixed collagen tissue disorder (4.8%), and systemic lupus erythematosus (1.6%). Pulmonary hypertension was present in 38.7% of the patients with the highest incidence of rheumatoid arthritis showing reduced respiratory functions, partial oxygen pressure, and six-minute walk distance, as well as increased serum pro-brain natriuretic peptide and neutrophilic alveolitis. Conclusion: High serum pro-brain natriuretic peptide levels and neutrophilic alveolitis may provide diagnostic clues for a possible diagnosis of pulmonary hypertension and impaired respiratory functions.