Extracellular Matrix and Regenerative Therapies from the Cardiac Perspective

Dogan A., Parmaksız M., Elçin A. E., Elçin Y. M.

STEM CELL REVIEWS AND REPORTS, vol.12, no.2, pp.202-213, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 12 Issue: 2
  • Publication Date: 2016
  • Doi Number: 10.1007/s12015-015-9641-5
  • Journal Name: STEM CELL REVIEWS AND REPORTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.202-213
  • Keywords: Extracellular matrix, Mechanotransduction, Heart, Stem cell therapy, Cardiac tissue engineering, Heart failure, Myocardial infarction, Tensegrity, ATRIAL-FIBRILLATION, STIFFNESS AFFECTS, GROWTH-FACTOR, HEART, CARDIOMYOCYTES, CELLS, DIFFERENTIATION, EXPRESSION, ANGIOGENESIS, SURVIVAL
  • Ankara University Affiliated: Yes

Abstract

Cardiovascular diseases are the leading cause of death and a major cause of financial burden. Regenerative therapies for heart diseases bring the promise of alternative treatment modalities for myocardial infarction, ischemic heart disease, and congestive heart failure. Although, clinical trials attest to the safety of stem cell injection therapies, researchers need to overcome the underlying mechanisms that are limiting the success of future regenerative options. This article aims to review the basic scientific concepts in the field of mechanobiology and the effects of extracellular functions on stem cell fate.