Extracellular Matrix and Regenerative Therapies from the Cardiac Perspective

Dogan A., Parmaksız M., Elçin A. E., Elçin Y. M.

STEM CELL REVIEWS AND REPORTS, cilt.12, sa.2, ss.202-213, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s12015-015-9641-5
  • Dergi Adı: STEM CELL REVIEWS AND REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.202-213
  • Anahtar Kelimeler: Extracellular matrix, Mechanotransduction, Heart, Stem cell therapy, Cardiac tissue engineering, Heart failure, Myocardial infarction, Tensegrity, ATRIAL-FIBRILLATION, STIFFNESS AFFECTS, GROWTH-FACTOR, HEART, CARDIOMYOCYTES, CELLS, DIFFERENTIATION, EXPRESSION, ANGIOGENESIS, SURVIVAL
  • Ankara Üniversitesi Adresli: Evet

Özet

Cardiovascular diseases are the leading cause of death and a major cause of financial burden. Regenerative therapies for heart diseases bring the promise of alternative treatment modalities for myocardial infarction, ischemic heart disease, and congestive heart failure. Although, clinical trials attest to the safety of stem cell injection therapies, researchers need to overcome the underlying mechanisms that are limiting the success of future regenerative options. This article aims to review the basic scientific concepts in the field of mechanobiology and the effects of extracellular functions on stem cell fate.