THE CORRELATION BETWEEN THE CLINICAL, LABORATORY AND HISTOPATHOLOGICAL FEATURES OF CHILDHOOD MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS AND RESPONSE TO TREATMENT

YALCINKAYA F., INCE E., TUMER N., EKIM M.

TURKISH JOURNAL OF PEDIATRICS, cilt.34, sa.3, ss.135-144, 1992 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 3
  • Basım Tarihi: 1992
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.135-144
  • Anahtar Kelimeler: CHILDHOOD, MEMBRANOGLOMERULONEPHRITIS, RESPONSE TO TREATMENT
  • Ankara Üniversitesi Adresli: Hayır

Özet

In this study, the clinical, laboratory and histopathological features of 50 children with membranoproliferative glomerulonephritis are reviewed. Age distribution varied from 5 to 15 years. The clinical presentation in the patients was nephrotic syndrome (24%), acute nephritic syndrome (20%) and nephritic/nephrotic syndrome (56%). Hypertension, macroscopic hematuria and hypocomplementemia were present in 40 percent, 58 percent and 34 percent of the patients, respectively. Light microscopic findings were as follows: glomerular lobulation (36%), mesangial sclerosis (20%), tubulointerstitial findings (36%), and crescents (26%). C3 (93%) was the most common immunofluorescence and IgM (86%), the most frequently encountered immunoglobulin. Response to treatment could not be anticipated by the initial clinical and laboratory features. Patients who did not have tubulointerstitial changes tended to have a greater response to therapy.