Cholesterol feeding attenuates endothelium-dependent relaxation response to acetylcholine in the main pulmonary artery of chickens

Aksulu H. E., Cellek S., Türker R.

European Journal of Pharmacology, cilt.129, sa.3, ss.397-400, 1986 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 129 Sayı: 3
  • Basım Tarihi: 1986
  • Doi Numarası: 10.1016/0014-2999(86)90456-5
  • Dergi Adı: European Journal of Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.397-400
  • Anahtar Kelimeler: Acetylcholine, Chickens, Endothelium-dependent relaxation, Hypercholesterolemia
  • Ankara Üniversitesi Adresli: Evet

Özet

The endothelium-dependent relaxation in response to acetylcholine was significantly less in pulmonary artery strips from chickens fed 5% cholesterol for 4 weeks than in strips from animals fed an 'ordinary' diet. No relaxation was observed in the strips from either group when the endothelium was disrupted or the strips were pretreated with hydroquinone. These results indicate that the relaxing effect of acetylcholine is endothelium-dependent and that hypercholesterolemia leads to an impairment of the endothelium-mediated relaxation response of the pulmonary artery strips to acetylcholine. © 1986.