The role of bcl-2 family of genes during kindling

AKÇALI K. C., Sahiner M., Sahiner T.

EPILEPSIA, vol.46, no.2, pp.217-223, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 2
  • Publication Date: 2005
  • Doi Number: 10.1111/j.0013-9580.2005.13904.x
  • Journal Name: EPILEPSIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.217-223
  • Keywords: apoptosis, kindling, bcl-2 family of genes, epilepsy, rat, TEMPORAL-LOBE EPILEPSY, INDUCED NEURONAL DAMAGE, STATUS EPILEPTICUS, KAINIC ACID, CELL-DEATH, ELECTRICAL STIMULATION, LIMBIC SEIZURES, RAT, APOPTOSIS, BAX
  • Ankara University Affiliated: No

Abstract

Purpose: Several experimental models of human temporal lobe epilepsy have shown that apoptotic death of neurons is an important part of this degenerative disease. However, the role of apoptotic regulators is not clear during the epileptogenesis. Therefore we investigated the expression pattern of bcl-2 family of genes during the formation of kindling model of epilepsy in rats.