ACTA VETERINARIA BRNO, cilt.77, sa.1, ss.81-88, 2008 (SCI-Expanded)
This study was performed to investigate the effects of alftizosin, doxazosin and tamsulosin in vitro on trigone smooth muscle of rabbit. In this study, fifteen rabbits weighing 2.5 - 3 kg were used. One strip in the shape of a trigone was prepared for each of the isolated bladders. Firstly, an initial tension of I g was placed on each segment, and we waited for equilibration by constantly bubbling with 95% O-2 and 5% CO2. Next, the determination level of electrical stimulation which created submaximal contraction and effective dosage were found for trigone and they were determined by applying different concentrations of phenylephrine (10(-8) M, 10(-7) M, 10(-6) M, 10(-5) M), respectively.