Relaxation responses of trigonal smooth muscle from rabbit by Alpha(1)-adrenoceptor antagonists alfuzosin, doxazosin and tamsulosin

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Karadeniz A., Piskin I., Essiz D., ALTINTAŞ L.

ACTA VETERINARIA BRNO, cilt.77, sa.1, ss.81-88, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 1
  • Basım Tarihi: 2008
  • Doi Numarası: 10.2754/avb200877010081
  • Dergi Adı: ACTA VETERINARIA BRNO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.81-88
  • Anahtar Kelimeler: trigone, rabbit, alfuzosin, doxazosin, tamsulosin, LOWER URINARY-TRACT, BENIGN PROSTATIC HYPERPLASIA, CURRENT CLINICAL-EXPERIENCE, SB 216469 ROLE, PHARMACOLOGICAL CHARACTERIZATION, ALPHA-1-ADRENOCEPTOR ANTAGONIST, ALPHA-1L ADRENOCEPTOR, MEDICAL-MANAGEMENT, TISSUE SELECTIVITY, ANESTHETIZED RATS
  • Ankara Üniversitesi Adresli: Evet

Özet

This study was performed to investigate the effects of alftizosin, doxazosin and tamsulosin in vitro on trigone smooth muscle of rabbit. In this study, fifteen rabbits weighing 2.5 - 3 kg were used. One strip in the shape of a trigone was prepared for each of the isolated bladders. Firstly, an initial tension of I g was placed on each segment, and we waited for equilibration by constantly bubbling with 95% O-2 and 5% CO2. Next, the determination level of electrical stimulation which created submaximal contraction and effective dosage were found for trigone and they were determined by applying different concentrations of phenylephrine (10(-8) M, 10(-7) M, 10(-6) M, 10(-5) M), respectively.