Familial Behcet's Disease of Adult Age: A Report of 4 Cases from a Behcet Family

GÜLBAY B., ACICAN T., Diken O. E., ÖNEN Z. P.

INTERNAL MEDICINE, cilt.51, sa.12, ss.1609-1611, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 12
  • Basım Tarihi: 2012
  • Doi Numarası: 10.2169/internalmedicine.51.6858
  • Dergi Adı: INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1609-1611
  • Anahtar Kelimeler: Behcet's disease, familial Behcet's disease, human leukocyte antigen, AGGREGATION, FREQUENCY
  • Ankara Üniversitesi Adresli: Evet

Özet

A familial aggregation of Behcet's disease (BD) has long been noted. These studies have supported the direct role of HLA-B5 in the pathogenesis of BD. Despite the fact that familial clustering is characterized by genetic anticipation, accounting for the earlier disease onset in successive generations, we present two brothers and two cousins from the same family who were diagnosed when they were over twenty years old. We report these young adult patients to introduce the characteristics of familial aggregation of BD. In this article HLA-B*51 and Cw*16 positivities with adult onset were demonstrated.