Synthesis and characterization of thermosensitive poly(N-vinylcaprolactam)-g-collagen

Durkut S., Elçin Y. M.

Artificial Cells, Nanomedicine and Biotechnology, vol.45, no.8, pp.1665-1674, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 8
  • Publication Date: 2017
  • Doi Number: 10.1080/21691401.2016.1276925
  • Journal Name: Artificial Cells, Nanomedicine and Biotechnology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1665-1674
  • Keywords: Thermosensitive polymer, poly(N-vinylcaprolactam)-g-collagen, biopolymer, controlled release, LCST, POLY N-ISOPROPYLACRYLAMIDE, DRUG-DELIVERY, THERMORESPONSIVE POLYMERS, MICROSPHERES, CYTOTOXICITY, HYDROGELS, NETWORKS, BEHAVIOR, GELATIN, RELEASE
  • Ankara University Affiliated: Yes

Abstract

© 2017 Informa UK Limited, trading as Taylor & Francis Group.In this study, we synthesized poly(N-vinylcaprolactam)-g-collagen (PNVCL-g-Col) by grafting collagen with carboxyl group-terminated thermosensitive PNVCL-COOH. The resulting biopolymer was evaluated for its structural, thermal, and rheological properties. Aqueous solutions of PNVCL-g-Col exhibited a temperature-dependent phase transition around human physiological temperature (at ∼38.5 °C), and temperature-dependent tunability. PNVCL-g-Col exhibited temperature-dependent release of the model drugs, lidocaine hydrochloride and bovine serum albumin. Thus, PNVCL-g-Col biopolymer may have wide potential use in various biomedical applications, including controlled release and tissue engineering.