Synthesis and characterization of thermosensitive poly(N-vinylcaprolactam)-g-collagen

Durkut S., Elçin Y. M.

Artificial Cells, Nanomedicine and Biotechnology, cilt.45, sa.8, ss.1665-1674, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 8
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/21691401.2016.1276925
  • Dergi Adı: Artificial Cells, Nanomedicine and Biotechnology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1665-1674
  • Anahtar Kelimeler: Thermosensitive polymer, poly(N-vinylcaprolactam)-g-collagen, biopolymer, controlled release, LCST, POLY N-ISOPROPYLACRYLAMIDE, DRUG-DELIVERY, THERMORESPONSIVE POLYMERS, MICROSPHERES, CYTOTOXICITY, HYDROGELS, NETWORKS, BEHAVIOR, GELATIN, RELEASE
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2017 Informa UK Limited, trading as Taylor & Francis Group.In this study, we synthesized poly(N-vinylcaprolactam)-g-collagen (PNVCL-g-Col) by grafting collagen with carboxyl group-terminated thermosensitive PNVCL-COOH. The resulting biopolymer was evaluated for its structural, thermal, and rheological properties. Aqueous solutions of PNVCL-g-Col exhibited a temperature-dependent phase transition around human physiological temperature (at ∼38.5 °C), and temperature-dependent tunability. PNVCL-g-Col exhibited temperature-dependent release of the model drugs, lidocaine hydrochloride and bovine serum albumin. Thus, PNVCL-g-Col biopolymer may have wide potential use in various biomedical applications, including controlled release and tissue engineering.