Serum C-reactive protein level is associated with renal function and it affects echocardiographic cardiovascular disease in pre-dialysis patients.

Ates K., Yilmaz O., Kutlay S., Ates A., Nergizoglu G., ERTÜRK Ş.

Nephron. Clinical practice, cilt.101, sa.4, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 101 Sayı: 4
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1159/000087414
  • Dergi Adı: Nephron. Clinical practice
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: pre-dialysis patients, C-reactive protein, creatinine clearance, left ventricular mass index, fractional shortening, serum albumin, hematocrit, LEFT-VENTRICULAR HYPERTROPHY, HEMODIALYSIS-PATIENTS, PERITONEAL-DIALYSIS, TNF-ALPHA, INFLAMMATION, FAILURE, INHIBITORS, MORTALITY, RISK, ATHEROSCLEROSIS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Relevance of serum CRP for morbidity and mortality in pre-dialysis patients has not been assessed extensively. The aim of this study was to determine the incidence of elevated serum CRP in pre-dialysis patients and to identify the factors that associate with serum CRP. We were also evaluated the effects of serum CRP on cardiovascular disease, anemia, and nutritional markers. METHODS: One hundred and eight pre-dialysis patients with a mean creatinine clearance (CrCl) of 30.1 ml/min were included in the study. Data collected from each patient included demographics, co-morbidity, medications, blood pressures, blood biochemistry including serum CRP, renal function, and echocardiography. RESULTS: Serum CRP was elevated (>5 mg/l) in 43 patients (39.8%). There was a negative correlation between serum CRP and CrCl (r = -0.370, p < 0.001). CrCl was the unique independent factor affecting serum CRP. Serum CRP was an independent factor affecting left ventricular mass index, fractional shortening, serum albumin and hematocrit in multivariate analyses. CONCLUSIONS: Prevalence of elevated serum CRP in pre-dialysis patients is high. Reduced renal clearance of CRP and/or cytokines may contribute to the inflammatory status. Elevated serum CRP is an important cause of morbidity in pre-dialysis patients. Copyright 2005 S. Karger AG, Basel.