Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis

Cakir U., Tayman C., Serkant U., Yakut H. I., Cakir E., ATEŞ U., ...More

JOURNAL OF ETHNOPHARMACOLOGY, vol.225, pp.297-308, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 225
  • Publication Date: 2018
  • Doi Number: 10.1016/j.jep.2018.07.009
  • Journal Name: JOURNAL OF ETHNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.297-308
  • Keywords: Necrotizing enterocolitis, Ginger, anti-oxidation, Anti-inflammation, Prevention, Newborn, Rat, TONGLING WHITE GINGER, NEONATAL-RAT MODEL, INTESTINAL BARRIER, ULCERATIVE-COLITIS, LIPID-PEROXIDATION, OXIDATIVE STRESS, ESSENTIAL OIL, PC12 CELLS, IN-VITRO, ANTIOXIDANT
  • Ankara University Affiliated: No

Abstract

Ethnopharmacological relevance: Necrotizing enterocolitis (NEC) is the most important gastrointestinal emergency affecting especially preterm infants and causes severe morbidities and mortality. However, there is no cure. Oxidant stress, inflammation, apoptosis, as well as prematurity are believed to responsible in the pathogenesis of the disease. Ginger and its compounds have anti-inflammatory, antimicrobial, anti-oxidant properties and immunomodulatory, cytoprotective/regenerative actions.