Association between paraoxonase activity and late saphenous vein graft occlusion in patients with coronary artery bypass grafting

Cagirci G., Cay S., Karakurt O., YAZIHAN N., Aydin C., Acikel S., ...Daha Fazla

KARDIOLOGIA POLSKA, cilt.67, sa.10, ss.1063-1069, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 10
  • Basım Tarihi: 2009
  • Dergi Adı: KARDIOLOGIA POLSKA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1063-1069
  • Anahtar Kelimeler: paraoxonase, saphenous vein graft, HUMAN-SERUM PARAOXONASE, HYPERCHOLESTEROLEMIC PATIENTS, ARYLESTERASE ACTIVITIES, OXIDIZED-LDL, DISEASE, THERAPY, LIPOPROTEINS, SEVERITY, PATENCY, MARKERS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Coronary vein graft disease is an important contributor to the morbidity after coronary artery bypass grafting (CABG). Late occlusion of the graft is a serious complication that limits the use of the saphenous vein as a coronary bypass conduit. It is frequently encountered in old, degenerated vein grafts with advanced atherosclerotic plaque formation. Paraoxonase-1 (PON-1) is an HDL-bound enzyme which has anti-atherogenic properties and protects LDL cholesterol from oxidative modification.