Association between paraoxonase activity and late saphenous vein graft occlusion in patients with coronary artery bypass grafting
KARDIOLOGIA POLSKA, cilt.67, sa.10, ss.1063-1069, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 67 Sayı: 10
- Basım Tarihi: 2009
- Dergi Adı: KARDIOLOGIA POLSKA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1063-1069
- Anahtar Kelimeler: paraoxonase, saphenous vein graft, HUMAN-SERUM PARAOXONASE, HYPERCHOLESTEROLEMIC PATIENTS, ARYLESTERASE ACTIVITIES, OXIDIZED-LDL, DISEASE, THERAPY, LIPOPROTEINS, SEVERITY, PATENCY, MARKERS
- Ankara Üniversitesi Adresli: Evet
Özet
Background: Coronary vein graft disease is an important contributor to the morbidity after coronary artery bypass grafting (CABG). Late occlusion of the graft is a serious complication that limits the use of the saphenous vein as a coronary bypass conduit. It is frequently encountered in old, degenerated vein grafts with advanced atherosclerotic plaque formation. Paraoxonase-1 (PON-1) is an HDL-bound enzyme which has anti-atherogenic properties and protects LDL cholesterol from oxidative modification.