Akademik Veri Yönetim Sistemi
32nd World Congress on Controversies in Obstetrics, Gynecology and Infertility, Lisbon, Portekiz, 21 - 24 Kasım 2024, ss.93-94, (Tam Metin Bildiri)
Problem statement: To investigate whether serum NGAL, MMP-9 and
MMP-9/NGAL ratio that are inflammatory markers and used for
diagnosis and follow-up in some diseases can be used as a diagnostic
and follow-up marker in the diagnosis of endometrioma in infertile
patients. Methods: 45 unexplained infertility patients and 45 infertile
patients with endometrioma were included in the study. Patients with
endometriomas of at least 3 cm in size were included in the study and
all patients were also diagnosed with endometrioma laparoscopically. A
venous blood sample were taken from the patients, centrifuged and
stored at -80 degrees. 3 months after the surgery, venous blood sample
were taken again. NGAL and MMP-9 levels from the venous blood
sample and MMP-9/NGAL ratio of the unexplained infertility and
endometrioma group and the preoperative and postoperative results of
the endometrioma group were compared. Results: The mean age
(35.2±6.3 vs 31.7±6.7) and AMH values (1.8±1.6 vs 3.3±2.3 ng/ml) were
different between endometrioma and unexplained infertility group,
respectively (p=0.001;p=0.003). The mean blood level of NGAL and
MMP-9 in endometrioma and unexplained group were 22.0±4.0 ng/ml
and 25.4±4.9 ng/ml; 43.7±8.0 ng/ml and 39.3±10.7 ng/ml respectively
and all results were statistically significant ( p=0.001;p=0.012). The
mean blood level of NGAL and MMP-9 in endometrioma and same
patients on postoperative third months were 24.9±4.9 ng/ml and
27.0±4.98 ng/ml; 43.9±7.3 ng/ml and 36.7±8.7 ng/ml, respectively
(p=0.179;p=0.006). The mean ratio of MMP-9/NGAL in endometrioma,
unexplained group and postoperative patients were 2.0±0.2, 1.5±0.2
and 1.4±0.2. All these results between endometrioma-unexplained
94
group and endometrioma-postoperative patients were statistically
significant (p=0.001;p=0.001). When we made a ROC curve analysis for
the presence of endometrioma, it was observed that the MMP-9/NGAL
ratio value greater than 1.75 had 86.1% sensitivity and 84 % specificity
in indicating the presence of endometrioma. (AUC=0.898).
Conclusion: Surprisingly, NGAL blood level was lesser in the
endometrioma group. MMP-9/NGAL ratio can be useful in the diagnosis
of endometrioma.