Extramedullary presentation of biclonal IgGκ and IgAκ multiple myeloma

Alanoǧlu G., Özet G., DALVA K., KUZU I., Erekul S., İLHAN O., ...Daha Fazla

Turkish Journal of Haematology, cilt.19, sa.3, ss.421-425, 2002 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2002
  • Dergi Adı: Turkish Journal of Haematology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.421-425
  • Anahtar Kelimeler: Biclonal gammopathy, Extramedullary myeloma, Lymphadenopathy, Multiple myeloma
  • Ankara Üniversitesi Adresli: Evet

Özet

Multiple myeloma is characterized by plasma cell infiltration of the bone marrow and the presence of a monoclonal protein in the plasma or the urine in 90% of cases. Major manifestations of the disease are bone pain, anemia, renal insufficiency and recurrent infections. Less frequent presentations are hepatic and splenic enlargement (5% of cases), lymphadenopathy (4%) and biclonal gammopathy (1%). In this report we describe a biclonal multiple myeloma presenting with cervical lymphadenopathy and sternal mass. The immunohistochemical study of the lymph node and the flow cytometric analysis of the bone marrow showed IgGκ and IgAκ biclonality. In this report the features of lymph node involvement and biclonality constitute a rare presentation of multiple myeloma.