The importance of studying inherited hematological disorders in ancient Anatolian populations

Alakoc Y., Akar N.

TURKISH JOURNAL OF HEMATOLOGY, cilt.28, sa.4, ss.257-263, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5152/tjh.2011.43
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.257-263
  • Anahtar Kelimeler: DNA, population genetics, molecular anthropology, factor V G1691A (Leiden), betathalassemia, sickle cell anemia, Anatolia, FACTOR-V-LEIDEN, BETA-GLOBIN GENE, MOLECULAR ANALYSIS, DNA EXTRACTION, THALASSEMIA, MUTATION, PREVALENCE, ANEMIA, DISEASES, ORIGIN
  • Ankara Üniversitesi Adresli: Evet

Özet

Before analysis of DNA from ancient remains was possible, anthropologists studied evolution and migration patterns using data obtained from population genetic studies on modern populations combined with data obtained from morphological evaluations of ancient remains. Currently, DNA analysis of ancient populations is making a valuable contribution to these efforts. Researchers that perform ancient DNA analysis prefer to study polymorphisms on the Y chromosome or mitochondrial DNA because the results are easier to statistically evaluate. To evaluate polymorphisms on diploid genomes, which are more informative, only mutations that have been extensively examined in modern populations should be chosen. The most extensively evaluated mutations are those related to prevalent inherited disorders. As such, beta-thalassemia, sickle cell anemia, FVL. mutation of globin and the factor V genes are good candidates for DNA studies in ancient populations. These mutations are common in Anatolia, host to many civilizations since the Paleolithic period. This history makes Anatolia a good place for conducting research that could enhance our understanding of human evolution and migration patterns. (Turk J Hematol 2011; 28: 257-63)