Does maternal VDR FokI single nucleotide polymorphism have an effect on lead levels of placenta, maternal and cord bloods?

AKYÜZLÜ D., Kayaalti Z., Soylemez E., Koca D., Soylemezoglu T.

PLACENTA, cilt.36, sa.8, ss.870-875, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.placenta.2015.06.012
  • Dergi Adı: PLACENTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.870-875
  • Anahtar Kelimeler: Vitamin D receptor (VDR), VDR FokI single nucleotide polymorphism, Lead exposure, Maternal blood, Placenta, Cord blood, VITAMIN-D-RECEPTOR, BONE-MINERAL DENSITY, DIETARY CALCIUM, TRANSCRIPTION FACTOR, GENE, ABSORPTION, CHILDREN, SUSCEPTIBILITY, MECHANISMS, WORKERS
  • Ankara Üniversitesi Adresli: Evet

Özet

Introduction: Individual susceptibility due to genetic variations appears to be an important factor in lead toxicity. As lead, ubiquitous atmospheric pollutant, behaves very similarly to calcium, gene polymorphisms in proteins involved in calcium homeostasis can affect lead toxicokinetics. Vitamin D receptor (VDR), a DNA-binding transcription factor, activates genes that encode proteins involved in calcium metabolism. Thus, the objective of this study was to determine the effect of maternal VDR FokI polymorphism on lead levels of maternal blood, placental tissue and cord blood.