Pathomorphological and Immunohistochemical Findings of Cystic Mucinous Hyperplasia of the Gall Bladder
ISRAEL JOURNAL OF VETERINARY MEDICINE, cilt.68, sa.4, ss.225-229, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 4
- Basım Tarihi: 2013
- Dergi Adı: ISRAEL JOURNAL OF VETERINARY MEDICINE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.225-229
- Anahtar Kelimeler: Dog, gall bladder, cystic mucinous hyperplasia, pathomorhology, immunohistochemistry, GALLBLADDER, EXPRESSION, P53
- Ankara Üniversitesi Adresli: Evet
Özet
A case of cystic mucinous hyperplasia is described in 5 years old, female, German Shepherd dog. Macroscopically the gall bladder was distended. There were multiple 0.1-0.3 cm size cystic papillary structures in many areas of gall bladder. In addition a 16 cm diameter paraovarian cyst containing serous fluid was detected in the cranial aspect of left ovary. Tissues were processed routinely and stained with haematoxylin-eosin (H&E) and Periodic Acid Shiff (PAS) stains. The gall bladder cysts contained a mucinous secretion and were lined with cuboidal epithelium. Immunohistochemically, TGF- beta 1, HER2 and Cx43 markers were mildly positive in cytoplasm of the gall bladder epithelial cells although there were no positive reactions with Ki67 and CEA markers.