Pathomorphological and Immunohistochemical Findings of Cystic Mucinous Hyperplasia of the Gall Bladder

Alcigir M. E., Polat I. M., Coskan A. S., Vural S., Vural M. R.

ISRAEL JOURNAL OF VETERINARY MEDICINE, cilt.68, sa.4, ss.225-229, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 4
  • Basım Tarihi: 2013
  • Dergi Adı: ISRAEL JOURNAL OF VETERINARY MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.225-229
  • Anahtar Kelimeler: Dog, gall bladder, cystic mucinous hyperplasia, pathomorhology, immunohistochemistry, GALLBLADDER, EXPRESSION, P53
  • Ankara Üniversitesi Adresli: Evet

Özet

A case of cystic mucinous hyperplasia is described in 5 years old, female, German Shepherd dog. Macroscopically the gall bladder was distended. There were multiple 0.1-0.3 cm size cystic papillary structures in many areas of gall bladder. In addition a 16 cm diameter paraovarian cyst containing serous fluid was detected in the cranial aspect of left ovary. Tissues were processed routinely and stained with haematoxylin-eosin (H&E) and Periodic Acid Shiff (PAS) stains. The gall bladder cysts contained a mucinous secretion and were lined with cuboidal epithelium. Immunohistochemically, TGF- beta 1, HER2 and Cx43 markers were mildly positive in cytoplasm of the gall bladder epithelial cells although there were no positive reactions with Ki67 and CEA markers.