Transcranial sonography imaging of brainstem raphe, substantia nigra and cerebral ventricles in patients with geriatric depression


Senel B., Ozel-Kizil E. T., SORGUN M. H., Tezcan-Aydemir S., Kirici S.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, cilt.35, sa.7, ss.702-711, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 7
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/gps.5287
  • Dergi Adı: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, PASCAL, Abstracts in Social Gerontology, AgeLine, BIOSIS, CINAHL, EMBASE, MEDLINE, Psycinfo, Public Affairs Index
  • Sayfa Sayıları: ss.702-711
  • Anahtar Kelimeler: brainstem raphe, diameter of ventricle, geriatric depression, substantia nigra, transcranial sonography, SUBJECTIVE MEMORY COMPLAINTS, MONTREAL COGNITIVE ASSESSMENT, LATE-LIFE DEPRESSION, PARKINSONS-DISEASE, MAJOR DEPRESSION, PSYCHOMETRIC PROPERTIES, MOVEMENT-DISORDERS, HEALTH-SERVICES, BASAL GANGLIA, OLDER-ADULTS
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives Geriatric depression is a special condition associated with a chronic course, treatment resistance and vascular processes. However, its neurobiology has not been fully elucidated. There is no study in geriatric depression evaluating deep brain structures with transcranial sonography (TCS) which is a low-cost, non-invasive and practical tool. The present study aimed to evaluate the changes in the echogenicity of brainstem raphe (BR), substantia nigra (SN) and ventricular diameters by TCS in association with cognitive dysfunctions in patients with geriatric depression. Methods Echogenicity of BR and SN were assessed and transverse diameters of the third ventricle and frontal horns of the lateral ventricles were measured by TCS in 34 patients with DSM-5 major depression and 31 healthy volunteers aged 60 and older. Cognitive functions were evaluated by using Mini Mental State Examination, Montreal Cognitive Assessment Tool, Clock Drawing Test and Subjective Memory Complaints Questionnaire. Results Although depressed patients had more subjective memory complaints than controls, they had similar cognitive performances. Reduced echogenicity (interrupted/invisible echogenic line) of BR was found to be significantly higher and the ventricular diameters were larger in the depressed group. There was no difference between the groups in terms of SN echogenicity. There was no correlation between ventricular diameters and depression severity or cognitive functions. Conclusions Results of the present study are important in terms of pointing out neurobiological changes related to geriatric depression which are in parallel with the results of the studies in younger patients with depression. However, long-term follow-up studies are required for accurate differentiation of neurocognitive disorders.