Effect of high-dose methylprednisolone and G-CSF treatments on lymphocyte subtypes in neutropenic children with acute lymphoblastic leukemia: A pilot study

Ozbek N., Yetgin S., Tuncer A.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.15, sa.6, ss.539-544, 1998 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 6
  • Basım Tarihi: 1998
  • Doi Numarası: 10.3109/08880019809018316
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.539-544
  • Anahtar Kelimeler: G-CSF, high-dose methylprednisolone, leukemia, lymphocyte subtypes, neutropenia, COLONY-STIMULATING FACTOR, CELLS
  • Ankara Üniversitesi Adresli: Hayır

Özet

Treatment of neutropenia with corticosteroids and hemopoietic growth factors may cause alterations in the immune system. This study investigated and compared the effects of various regimens (HDMP, G-CSF, and G-CSFS HDMP) on total lymphocyte counts and subtypes in neutropenic patients with acute lymphoblastic leukemia. Lymphocyte subtypes were studied just prior to treatment and 1 week later: In the HDMP group, total lymphocyte counts and the numbers of CD3(+), CD4(+), CD8(+), and CD19(+) lymphocytes and monocytes increased, while the helper/supressor lymphocyte ratio decreased. No significant changes were sea in lymphocyte subtypes in the G-CSF and G-CSF + HDMP groups, apart from an increase in total lymphocyte numbers. In the control group there was an increase in the number of CD3(+) and CD8(+) lymphocytes and a decrease in the helper/supressor lymphocyte ratio. These results suggest that HDMP has an inducing, rather than a suppressive effect on all lymphocyte subtypes studied.