Cyclisation of 3-alkenylpyrido[1,2-a]pyrimidines to furo[2,3-d]pyrido[1,2-a]pyrimidines

GÜLLÜ M., Uzun S., Yulcun S.

TETRAHEDRON LETTERS, cilt.44, sa.9, ss.1939-1941, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 9
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0040-4039(03)00087-x
  • Dergi Adı: TETRAHEDRON LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1939-1941
  • Anahtar Kelimeler: cyclisation, furopyridopyrimidines, pyridopyrimidines, VARICELLA-ZOSTER VIRUS, SELECTIVE-INHIBITION, POTENT
  • Ankara Üniversitesi Adresli: Evet

Özet

3-Alkenylpyrido[1,2-a]pyrimidines react under mild conditions to give novel tricyclic furo[2,3-d]pyrido[1,2-a]pyrimidines in high yields. The cyclisation takes place in the presence of an acid catalyst. The product yield is affected by the type and the strength of the acid used. Exceptionally high yields were obtained when an organic acid like trifluoromethanesulfonic acid and trifluoroacetic acid were used. On the other hand, sulfuric acid gave the best results of the inorganic acids examined. (C) 2003 Elsevier Science Ltd. All rights reserved.