Tumour necrosis factor-alpha in diastolic dysfunction
ACTA CARDIOLOGICA, vol.59, no.5, pp.507-510, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 59 Issue: 5
- Publication Date: 2004
- Doi Number: 10.2143/ac.59.5.2005224
- Journal Name: ACTA CARDIOLOGICA
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.507-510
- Keywords: tumour necrosis factor-alpha, diastolic dysfunction, abnormal relaxation, TNF-ALPHA
- Ankara University Affiliated: Yes
Abstract
Background - Active relaxation develops as a result of sequestration of calcium into the sarcoplasmic reticulum, and is controlled mainly by sarcoplasmic reticulum calcium ATPase (SERCA) and phospholamban. Tumour necrosis factor-alpha (TNF-alpha) downregulates both of these proteins, so it may play a role in the development of abnormal relaxation. However, a possible relationship between TNF-alpha and diastolic dysfunction has not been sufficiently evaluated in vivo. We investigated whether circulating levels of TNF-alpha increased in patients with relaxation abnormality.