Tumour necrosis factor-alpha in diastolic dysfunction
ACTA CARDIOLOGICA, cilt.59, sa.5, ss.507-510, 2004 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 59 Sayı: 5
- Basım Tarihi: 2004
- Doi Numarası: 10.2143/ac.59.5.2005224
- Dergi Adı: ACTA CARDIOLOGICA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.507-510
- Anahtar Kelimeler: tumour necrosis factor-alpha, diastolic dysfunction, abnormal relaxation, TNF-ALPHA
- Ankara Üniversitesi Adresli: Evet
Özet
Background - Active relaxation develops as a result of sequestration of calcium into the sarcoplasmic reticulum, and is controlled mainly by sarcoplasmic reticulum calcium ATPase (SERCA) and phospholamban. Tumour necrosis factor-alpha (TNF-alpha) downregulates both of these proteins, so it may play a role in the development of abnormal relaxation. However, a possible relationship between TNF-alpha and diastolic dysfunction has not been sufficiently evaluated in vivo. We investigated whether circulating levels of TNF-alpha increased in patients with relaxation abnormality.