Tumour necrosis factor-alpha in diastolic dysfunction

Kilickap M., Gurlek A., Dandachi R., DİNÇER İ., Tutkak H., Oral D.

ACTA CARDIOLOGICA, cilt.59, sa.5, ss.507-510, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 5
  • Basım Tarihi: 2004
  • Doi Numarası: 10.2143/ac.59.5.2005224
  • Dergi Adı: ACTA CARDIOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.507-510
  • Anahtar Kelimeler: tumour necrosis factor-alpha, diastolic dysfunction, abnormal relaxation, TNF-ALPHA
  • Ankara Üniversitesi Adresli: Hayır

Özet

Background - Active relaxation develops as a result of sequestration of calcium into the sarcoplasmic reticulum, and is controlled mainly by sarcoplasmic reticulum calcium ATPase (SERCA) and phospholamban. Tumour necrosis factor-alpha (TNF-alpha) downregulates both of these proteins, so it may play a role in the development of abnormal relaxation. However, a possible relationship between TNF-alpha and diastolic dysfunction has not been sufficiently evaluated in vivo. We investigated whether circulating levels of TNF-alpha increased in patients with relaxation abnormality.