Coating of micropellets containing sodium salicylate using Fluid-bed method

Canefe K., HASÇİÇEK C.

Acta Pharmaceutica Turcica, cilt.38, sa.4, ss.117-121, 1996 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 4
  • Basım Tarihi: 1996
  • Dergi Adı: Acta Pharmaceutica Turcica
  • Derginin Tarandığı İndeksler: Scopus, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.117-121
  • Anahtar Kelimeler: coating, Fluid-bed, micropellet, pelletization
  • Ankara Üniversitesi Adresli: Evet

Özet

The aim of this study was to develop suitable micropellet formulations which contain sodium salicylate as a model drug by using Fluid-bed method. Within-process and quality controls that were conducted during these procedures, the investigation of the productivity and efficiency of the products was also aimed. Micropellet formulations which contain sodium salicylate could have irritating effect to the stomach, so micropellets were enteric coated in order to have a smooth surface and also to release drug in the intestinal tract. The release of drug from micropellets was examined by dissolution rate studies and kinetic equations were analysed.