Akademik Veri Yönetim Sistemi
Radiation Physics and Chemistry, cilt.245, 2026 (SCI-Expanded, Scopus)
This study investigates, to the best of our knowledge, the dosimetric feasibility of dry gelatin material (DGM) pellets derived from bovine (high bloom) and porcine (low bloom) sources as tissue-equivalent Electron Spin Resonance (ESR) dosimeters for clinical radiotherapy. The pellets were exposed to 6 MV photon beams in the clinical dose range of 0.2–10 Gy using a linear accelerator (LINAC). Comprehensive analyses, including Fourier transform infrared (FTIR) spectroscopy, microhardness tests, and particle size analysis, were conducted to elucidate the influence of biological origin, specifically bloom strength and particle size distribution, on dosimetric performance. The results revealed that while the higher bloom strength of bovine gelatin led to larger particle agglomeration, the porcine DGM exhibited superior physical homogeneity and mechanical precision. Both DGM types demonstrated promising dose-response linearity (R2≈0.995) comparable to commercial TLD-100 and BeO dosimeters. Although a significant signal fading of approximately 47% was observed over 84 days for both materials, the decay kinetics followed a predictable double-exponential model (R2>0.991), allowing for precise dose estimation using a fading correction factor (FCF). Interestingly, the fading characteristics were found to be governed by the amorphous matrix structure rather than the polypeptide chain length associated with bloom strength. The study concludes that with appropriate background and fading corrections, DGM pellets offer a promising, cost-effective, and sustainable alternative for clinical quality assurance applications as ESR dosimeters. Furthermore, these findings pave the way for future research into their application for in vivo dosimetry and seamless integration into routine clinical radiotherapy workflows.