Reference values of serum cystatin C in very low-birthweight premature infants

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Demirel G., Celik I. H., Canpolat F. E., ERDEVE Ö., Biyikli Z., Dilmen U.

ACTA PAEDIATRICA, vol.102, no.1, 2013 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 102 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1111/apa.12041
  • Journal Name: ACTA PAEDIATRICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Creatinine, Cystatin C, Reference ranges, Very low-birthweight infant, GLOMERULAR-FILTRATION-RATE, CREATININE
  • Ankara University Affiliated: Yes

Abstract

Aim To determine reference values for cystatin C (CysC) and its correlation with creatinine (Cr), gestational age, birthweight and maternal Cr status in very low-birthweight (VLBW) preterm infants. Method The study included 113 VLBW premature infants (<1500 g) of =32 gestational week. Serum Cr and CysC of the infant and serum Cr of the mother were analysed. Results The mean level of CysC was 1.77 +/- 0.38 mg/L on day 1 and 1.61 +/- 0.37 mg/L on day 3, and the decrease was statistically significant. There was a significant correlation only between maternal Cr and first-day Cr values and negative correlations between Cr and gestational age and birthweight on third day. Creatinine was not correlated with CysC both on day 1 (r = -0.077, p = 0.417) and day 3 (r = 0.132, p = 0.164). Conclusion Here, we report the reference ranges for CysC and Cr on first and third day in VLBW infants. CysC concentrations significantly decrease by day 3 compared with day 1 and are independent of gestational week, birthweight and maternal renal function status in VLBW preterm infants.