Water-immiscible room temperature ionic liquids (RTILs) as drug reservoirs for controlled release

Jaitely V., Karatas A., Florence A. T.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, cilt.354, sa.1-2, ss.168-173, 2008 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 354 Sayı: 1-2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.ijpharm.2008.01.034
  • Dergi Adı: INTERNATIONAL JOURNAL OF PHARMACEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.168-173
  • Anahtar Kelimeler: room temperature ionic liquids (RTILs), 1-alkyl-3-methylimidazolium salts, controlled release, partitioning, reservoir, ORGANIC-SOLVENTS
  • Ankara Üniversitesi Adresli: Evet

Özet

Water-immiscible room temperature ionic liquids (RTILs) have a largely unexplored potential as pharmaceutical solvents and reservoirs. This paper explores some relevant properties of the hexafluorophosphate (PF6-) salts of butyl, hexyl and octyl-3-methytimidazolium cations (BMIM, HMIM, OMIM, respectively). The dodecyl analogue is solid at room temperature, but its melting point can be lowered by addition of the lower homologues. Although water-immiscible, the liquids absorb water to an extent depending on their structure, the higher alkyl analogues having a lower affinity for absorbed water. The RTIL/water partition coefficients of sucrose, penicillin V potassium, dexametasone, progesterone and dehydro-epiandrosterone have been compared with octanol-water coefficients. The viscosities of the salts were measured in anhydrous, water-saturated and intermediate states. The PF6- ionic liquids display a low and decreasing aqueous solubility as the alkyl chain length is increased: 0.035 mol l(-1) (BMIM), 0.032 mol l(-1) (HMIM) and 0.09 mol l(-1) (OMIM). The release of sucrose and dexametasone from RTIL reservoirs into water can be prolonged over 48 h. Saturated solutions of these RTILs show little toxicity towards Caco-2 cells, although the OMIM derivative, which is more surface-active, has a small effect on cell viability. (C) 2008 Elsevier B.V. All rights reserved.