Neutrophil volume, conductivity and scatter parameters with effective modeling of molecular activity statistical program gives better results in neonatal sepsis

Celik I. H., Demirel G., Sukhachev D., Erdeve Ö., Dilmen U.

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, vol.35, no.1, pp.82-87, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1111/ijlh.12002
  • Journal Name: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.82-87
  • Keywords: Neutrophil volume, conductivity and scatter parameters, effective modeling of molecular activity statistical program, neonatal sepsis, C-REACTIVE PROTEIN, AUTOMATED-DETERMINATION, BACTERIAL-INFECTIONS, VCS PARAMETERS, INTERLEUKIN-6, DIAGNOSIS, INDICATORS, PREDICTION
  • Ankara University Affiliated: Yes

Abstract

Introduction: Neonatal sepsis remains an important clinical syndrome despite advances in neonatology. Current hematology analyzers can determine cell volume (V), conductivity for internal composition of cell (C) and light scatter for cytoplasmic granularity and nuclear structure (S), and standard deviations which are effective in the diagnosis of sepsis. Statistical models can be used to strengthen the diagnosis. Effective modeling of molecular activity (EMMA) uses combinatorial algorithm of the selection parameters for regression equation based on modified stepwise procedure. It allows obtaining different regression models with different combinations of parameters.