New Insights into Peritrophic Matrix Synthesis, Architecture, and Function

Hegedus D., Erlandson M., Gillott C., TOPRAK U.

ANNUAL REVIEW OF ENTOMOLOGY, cilt.54, ss.285-302, 2009 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 54
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1146/annurev.ento.54.110807.090559
  • Dergi Adı: ANNUAL REVIEW OF ENTOMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.285-302
  • Anahtar Kelimeler: chitin, chitin binding protein, glycosylation, mucin, structure, MAMESTRA-CONFIGURATA LEPIDOPTERA, CHITIN-SYNTHASE GENES, INTESTINAL MUCIN, SPODOPTERA-FRUGIPERDA, ANOPHELES-GAMBIAE, LUCILIA-CUPRINA, AEDES-AEGYPTI, LARVAL MIDGUT, SECRETORY MECHANISMS, DIGESTIVE ENZYMES
  • Ankara Üniversitesi Adresli: Hayır

Özet

The peritrophic matrix (PM) is a chitin and glycoprotein layer that lines the invertebrate midgut. Although structurally, different, it is functionally similar to the mucous secretions of the vertebrate digestive tract. 11, he PM is a physical harrier, protecting the midgut epithelium from abrasive food particles, digestive enzymes, and pathogens infectious per os. It is also a biochemical harrier, sequestering and, ill some cases, inactivating ingested toxins. Finally, the PM compartmentalizes digestive processes, allowing for efficient nutrient acquisition and reuse Of hydrolytic enzymes. The PM consists of an organized lattice of chitin fibrils held together by chitin binding proteins. Glycans fill the interstitial spaces, creating a molecular sieve, the properties of which are dependent oil the immediate ion content and pH. In this review, we have integrated recent Structural and functional information to create a holistic model for the PM. We also show how this information may generate novel technologies for use ill insect pest management.