The Effects of Caffeic Acid Phenethyl Ester and Ellagic Acid on the Levels of Malondialdehyde, Reduced Glutathione and Nitric Oxide in the Lung, Liver and Kidney Tissues in Acute Diazinon Toxicity in Rats

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Alp H., Aytekin I., Atakisi O., Hatipoglu N. K., Basarali K., ÖĞÜN M., ...More

JOURNAL OF ANIMAL AND VETERINARY ADVANCES, vol.10, no.11, pp.1488-1494, 2011 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 11
  • Publication Date: 2011
  • Doi Number: 10.3923/javaa.2011.1488.1494
  • Journal Name: JOURNAL OF ANIMAL AND VETERINARY ADVANCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1488-1494
  • Keywords: Caffeic acid phenethyl ester, diazinon, ellagic acid, malondialdehyde, nitric oxide, reduced glutathione, ERYTHROCYTES IN-VITRO, OXIDATIVE STRESS, LIPID-PEROXIDATION, ANTIOXIDANT ENZYMES, CHLORPYRIFOS-ETHYL, PROTECTIVE ROLE, VITAMIN-C, DAMAGE, MECHANISM, BLOOD
  • Ankara University Affiliated: Yes

Abstract

The aim of this study was to investigate the effects of Caffeic Acid Phenethyl Ester (CAPE) and Ellagic Acid (EA) on acitivities of Malondialdehyde (MDA), reduced Glutathione (GSH) and Nitric Oxide (NO) in rat lung, liver and kidney tissues in acute Diazinon (DI) toxicity. Six groups of 6 Sprague Dawley rats were used comprising control, CAPE, EA, DI control, DI+CAPE and DI+EA. Tissue samples were analysed for GSH, MDA and NO levels in lung, liver and kidney tissues. Biochemical parameters were measured colormetrically by spectrophotometer. Control, CAPE and EA groups showed no statistically significant difference whereas DI+medication groups revealed that CAPE and EA increased the level of GSH in liver tissue by blocking the DI effect. NO levels in lung, liver and kidney tissues were significantly increased by DI but CAPE and EA attenuated those levels. In DI+medication groups, MDA levels showed no significant change in kidney and liver tissues but in lung tissues, CAPE and EA reduced the MDA level by blocking the DI effect. It was concluded that CAPE and EA which showed similar effects to each other could be used for protection and support against oxidative stress caused by acute DI intoxication.