Translational applications of tissue engineering in cardiovascular medicine

Dogan A., Elçin A. E., Elçin Y. M.

Current Pharmaceutical Design, cilt.23, sa.6, ss.903-914, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 23 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1381612823666161111141954
  • Dergi Adı: Current Pharmaceutical Design
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.903-914
  • Anahtar Kelimeler: Cardiovascular tissue engineering, vascular tissue engineering, heart valve tissue engineering, angiogenesis, myocardial infarction, cardiac patch, injectable biomaterials, drug testing, decellularization, extracellular matrix, ENDOTHELIAL GROWTH-FACTOR, MICROSPHERES IN-VITRO, EMBRYONIC STEM-CELLS, EXTRACELLULAR-MATRIX, CARDIAC TISSUE, HEART-VALVES, PROGENITOR CELLS, VASCULAR GRAFT, CONTROLLED-RELEASE, MYOCARDIAL MATRIX
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2017 Bentham Science Publishers.Cardiovascular diseases are the leading cause of global deaths. The current paradigm in medicine seeks novel approaches for the treatment of progressive or end-stage diseases. The organ transplantation option is limited in availability, and unfortunately, a significant number of patients are lost while waiting for donor organs. Animal studies have shown that upon myocardial infarction, it is possible to stop adverse remodeling in its tracks and reverse with tissue engineering methods. Regaining the myocardium function and avoiding further deterioration towards heart failure can benefit millions of people with a significantly lesser burden on healthcare systems worldwide. The advent of induced pluripotent stem cells brings the unique advantage of testing candidate drug molecules on organ-on-chip systems, which mimics human heart in vitro. Biomimetic three-dimensional constructs that contain disease-specific or normal cardiomyocytes derived from human induced pluripotent stem cells are a useful tool for screening drug molecules and studying dosage, mode of action and cardio-toxicity. Tissue engineering approach aims to develop the treatments for heart valve deficiency, ischemic heart disease and a wide range of vascular diseases. Translational research seeks to improve the patient’s quality of life, progressing towards developing cures, rather than treatments. To this end, researchers are working on tissue engineered heart valves, blood vessels, cardiac patches, and injectable biomaterials, hence developing new ways for engineering bio-artificial organs or tissue parts that the body will adopt as its own. In this review, we summarize translational methods for cardiovascular tissue engineering and present useful tables on pre-clinical and clinical applications.