Statin pretreatment and risk of in-hospital atrial fibrillation among patients undergoing cardiac surgery: a collaborative meta-analysis of 11 randomized controlled trials

Patti, Giuseppe; Bennett, Rachel; Seshasai, Sreenivasa; Cannon, Christopher; Cavallari, Ilaria; Chello, Massimo; Nusca, Annunziata; Mega, Simona; Caorsi, Carlos; Spadaccio, Cristiano; On, Young; Mannacio, Vito; Berkan, Ocal; YILMAZ, MEHMET; Katrancioglu, Nurkay; Ji, Qiang; Kourliouros, Antonios; BARAN, ÇAĞDAŞ; Pasceri, Vincenzo; AKAR, AHMET; Kaski, Juan; Di Sciascio, Germano; Ray, Kausik

doi:10.1093/europace/euv001

Statin pretreatment and risk of in-hospital atrial fibrillation among patients undergoing cardiac surgery: a collaborative meta-analysis of 11 randomized controlled trials

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Patti G., Bennett R., Seshasai S. R. K., Cannon C. P., Cavallari I., Chello M., ...More

EUROPACE, vol.17, no.6, pp.855-863, 2015 (SCI-Expanded)

Publication Type: Article / Article
Volume: 17 Issue: 6
Publication Date: 2015
Doi Number: 10.1093/europace/euv001
Journal Name: EUROPACE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.855-863
Keywords: Statins, Cardiac surgery, Postoperative atrial fibrillation, Meta-analysis, ENDOTHELIAL PROGENITOR CELLS, PREOPERATIVE STATINS, UPSTREAM THERAPIES, CLINICAL-EVIDENCE, CORONARY SURGERY, EUROPEAN-SOCIETY, BYPASS-SURGERY, DOUBLE-BLIND, TROPONIN-I, ATORVASTATIN
Ankara University Affiliated: Yes

Abstract

Aims Statin pretreatment in patients undergoing cardiac surgery is understood to prevent postoperative atrial fibrillation (AF). However, this is based on observational and limited randomized trial evidence, resulting in uncertainty about any genuine anti-arrhythmic benefits of these agents in this setting. We therefore aimed to quantify precisely the association between statin pretreatment and postoperative AF among patients undergoing cardiac surgery.