Electrochemical characterization of SnO2/rGO nanostructure for selective quantification of captopril in real matrix
Journal of Materials Research, cilt.38, sa.10, ss.2764-2774, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 10
- Basım Tarihi: 2023
- Doi Numarası: 10.1557/s43578-023-01000-1
- Dergi Adı: Journal of Materials Research
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, ABI/INFORM, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
- Sayfa Sayıları: ss.2764-2774
- Anahtar Kelimeler: Anti-hypertension drug, Captopril, Graphene oxide nanostructures, Sensor, Tin oxide
- Ankara Üniversitesi Adresli: Evet
Özet
Captopril (CAP) is one of the most broadly consumed anti-hypertension drug that caused various harmful effects such as zinc deficiency, cough, agranulocytosis, and angioedema. Thus, monitoring the low-level concentration of CAP through reliable and sensitive method is of great significance. The electrocatalytic properties of newly fabricated sensor based on SnO2/rGO/PtE was evaluated through Tafel plot and electrochemical impedance spectroscopy. The engineered sensor exhibited excellent response for CAP under optimal conditions e.g., PBS electrolyte (pH 5), scan sweep 90 mV/s and potential window (0.6 to 1.9 V). For effectiveness of developed sensor, two low and high concentration ranges of CAP were optimized as 1 to 700 nM and 10 100 µM, respectively. The LOD’s of SnO2/rGO/PtE for CAP for low and high concentrations were calculated as 0.061 nM and 0.0018 µM. Moreover, the exceptional long-term stability and anti-interference profile of SnO2/rGO/PtE suggested the reliability of chemically modified sensor. Graphical Abstract: [Figure not available: see fulltext.].