Electrochemical characterization of SnO2/rGO nanostructure for selective quantification of captopril in real matrix

Buledi J. A., Solangi A. R., Malah A., Memon S. Q., Mahar N., Ali S., ...Daha Fazla

Journal of Materials Research, cilt.38, sa.10, ss.2764-2774, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 10
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1557/s43578-023-01000-1
  • Dergi Adı: Journal of Materials Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, ABI/INFORM, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.2764-2774
  • Anahtar Kelimeler: Anti-hypertension drug, Captopril, Graphene oxide nanostructures, Sensor, Tin oxide
  • Ankara Üniversitesi Adresli: Evet

Özet

Captopril (CAP) is one of the most broadly consumed anti-hypertension drug that caused various harmful effects such as zinc deficiency, cough, agranulocytosis, and angioedema. Thus, monitoring the low-level concentration of CAP through reliable and sensitive method is of great significance. The electrocatalytic properties of newly fabricated sensor based on SnO2/rGO/PtE was evaluated through Tafel plot and electrochemical impedance spectroscopy. The engineered sensor exhibited excellent response for CAP under optimal conditions e.g., PBS electrolyte (pH 5), scan sweep 90 mV/s and potential window (0.6 to 1.9 V). For effectiveness of developed sensor, two low and high concentration ranges of CAP were optimized as 1 to 700 nM and 10 100 µM, respectively. The LOD’s of SnO2/rGO/PtE for CAP for low and high concentrations were calculated as 0.061 nM and 0.0018 µM. Moreover, the exceptional long-term stability and anti-interference profile of SnO2/rGO/PtE suggested the reliability of chemically modified sensor. Graphical Abstract: [Figure not available: see fulltext.].