Toxic Effects of Xenobiotics on DNA and Toxicogenetics

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Ozdemir F., Kayaalti Z., AKYÜZLÜ D.

MARMARA PHARMACEUTICAL JOURNAL, cilt.19, sa.3, ss.246-251, 2015 (ESCI) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.12991/mpj.20151927137
  • Dergi Adı: MARMARA PHARMACEUTICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.246-251
  • Anahtar Kelimeler: Toxicogenetics, genetic toxicology, toxic agent, mu-, COMET ASSAY, GENETIC-BASIS, DAMAGE, POLYMORPHISM, BLOOD, LEAD
  • Ankara Üniversitesi Adresli: Evet

Özet

Nutrition, drugs, environmental and industrial xenobiotics and various substances have a toxic effect on DNA, cause mutations and have teratogenic effects. The response against these mutagens can be different between individuals due to the genetic polymorphisms. The studies examining the effects of toxic agents on DNA are reffered to as "genetic toxicology" and the studies examining the effects of variations in DNA on the toxicokinetics and toxicodynamics of toxic agents are referred to as "toxicogenetics". Toxicogenetic researches have been increased after, especially the Human Genome Project, it has been reported that these individual differences are related to traits that are inherited genetically. Nowadays, genetic toxicology and toxicogenetic become important scientific fields. So, carcinogen xenobiotics which affect DNA and cause to changes on DNA were mentioned as a field of genetic toxicology and toxicogenetic researches which mainly have been done on Turkish population was mentioned in present review.