Akademik Veri Yönetim Sistemi
Acta Pharmaceutica Turcica, cilt.39, sa.1, ss.15-26, 1997 (Scopus)
Temperature, process period and settlement order in the autoclave applied during the sterilization procedure of parenteral preparations, prepared under specific study conditions, by heat cause many stability problems. The samples prepared in our laboratory and commercial preparations containing three agents, namely aminophylline, furosemid and verapamil, were used. They were studied to sterilization process at 121°C for 20, 30 and 60 minutes. The changes that occurred due to different settlement order in the autoclave during sterilization has been established through organoleptic controls, pH change and the determination of the amount of the agent. Besides, the effect of the structure of autoclaves, differing in their capacities and sizes, the effect of the amount of agent was also controlled in this study. In our investigations, it was determined that formulations of aminophylline with a pH value of 8.8, of furosemid with a pH value of 9.2 and of verapamil with a pH value of 4.5 were more stable than the others. In addition it was found that furosemid was more stable at its peak pH value and aminophylline and verapamil at their base pH values. On the other hand, it was found that pursued by autoclaves that have different sizes and the different order of settlement in the autoclave, samples setting closer to the walls of the autoclave degraded more. The particular change in the degradation of the preparations was not obtained by using different types of autoclaves.