Derivation of a biological limit value (BLV) for inorganic lead based on lead-induced genotoxicity in workers using the benchmark dose approach (BMD)

DUYDU Y.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, cilt.69, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.jtemb.2021.126894
  • Dergi Adı: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Occupational lead exposure, Lead-induced SCE frequencies, Benchmark dose, Biological limit value, Quantitative dose-response, DELTA-AMINOLEVULINIC-ACID, DEHYDRATASE ALAD POLYMORPHISM, CHROMATID EXCHANGE SCE, RESPONSE RELATIONSHIPS, OCCUPATIONAL-EXPOSURE, BLOOD LEAD, LYMPHOCYTES, FREQUENCIES, CELLS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Safe exposure levels for industrial chemicals are a prerequisite to the safety of workers in occupational settings. Methods: The application areas of the benchmark dose (BMD) approach have tremendously increased in recent years. Quantitative analyzes of dose-response relationships of genotoxic chemicals are among these application areas too. This study investigates the applicability of sister chromatid exchange (SCE) frequencies in lymphocytes of lead-exposed workers to derive a biological limit value (BLV) for inorganic lead. To this end, our previously published occupational lead exposure data were pooled and re-examined by using the BMD approach. Subsequently, we determined the point of departure (POD) value for lead-induced SCE frequencies in lymphocytes. Accordingly, the blood lead concentrations and SCE frequencies in lymphocytes of 26 control and 108 lead exposed male voluntary workers employed in a battery manufacturing plant were subjected to BMD modeling to determine the BMD confidence interval (BMD-CI). Results: According to our data set, benchmark dose lower bound (BMDL) of 6.55 mu g Pb/dL blood for the SCE frequencies in lymphocytes of lead-exposed workers has been obtained. Conclusion: The blood lead concentration of 6.55 mu g/dL might be proposed as the BLV for lead and its inorganic lead compounds based on our dataset.