Akademik Veri Yönetim Sistemi
Analytical Letters, 2025 (SCI-Expanded)
This study investigated the chemical composition and anti-inflammatory properties of fourteen wild mushroom species from Türkiye. Extracts were obtained through maceration and ultrasonic-assisted extraction. Metabolites, including polyols, phenolics, and organic acids, were analyzed by gas chromatography–mass spectrometry (GC-MS). Anti-inflammatory activity was determined spectrophotometrically using luminol-enhanced chemiluminescence. The main polyols detected were mannitol, xylitol, erythritol, ribitol, and glycerol, with mannitol being predominant. Macrolepiota procera contained the highest mannitol (3597 mg/100 g dry mass) and erythritol (23.29 mg/100 g dry mass) levels. Inocutis rheades and Daedalea quercina showed high xylitol (>2000 mg/100 g dry mass), while Omphalotus olearius was richest in glycerol (1179 mg/100 g dry mass). Ultrasonication generally improved polyol yields compared to maceration, and extended soaking followed by short ultrasonication further enhanced metabolite recovery. Among the species, Phaeolus schweinitzii exhibited the most potent anti-inflammatory effect (IC50:6.6 ± 0.6 µg/mL), surpassing ibuprofen (IC50:15.5 ± 2.1 µg/mL). Leptoporus mollis also showed strong activity (IC50:14.5 ± 2.0 µg/mL), while Hymenochaete rubiginosa (IC50:28.6 ± 0.1 µg/mL) and Phellinus igniarius (IC50:40.2 ± 5.2 µg/mL) displayed notable inhibition. Overall, phenolic acids and unsaturated fatty acids contributed significantly to anti-inflammatory effects, while polyols supported activity. The results highlight P. schweinitzii and L. mollis as promising natural anti-inflammatory sources, while mannitol- and xylitol-rich mushrooms offer both nutraceutical and industrial potential.