Evaluation of serum pregnancy associated plasma protein-A levels in patients with rheumatoid arthritis Romatoid artrit hastalarında serum gebelikle ilişkili plazma protein-A düzeylerinin incelenmesi
Journal of Turkish Society For Rheumatology, cilt.12, sa.2, ss.45-50, 2020 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12 Sayı: 2
- Basım Tarihi: 2020
- Doi Numarası: 10.4274/raed.galenos.2020.29291
- Dergi Adı: Journal of Turkish Society For Rheumatology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.45-50
- Anahtar Kelimeler: activity, PAPP-A, pregnancy-associated plasma protein-A, Rheumatoid arthritis
- Ankara Üniversitesi Adresli: Evet
Özet
Objective: Rheumatoid arthritis (RA) is a systemic disorder characterized by inflammatory arthritis. Coronary artery diseases (CADs) are important reason for mortality in RA. Pregnancy-associated plasma protein-A (PAPP-A) is independently related to cardiovascular events in patients with CAD and it could be a sensitive biomarker of disease activity in inflammatory diseases. In this study, we aimed to measure serum PAPP-A level and assess the association with disease activity parameters in patients with RA. Methods: A total of 55 RA patients underwent to clinical (disease activity score-DAS28), laboratory [erythrocyte sedimentation rate (ESR), C-reactive protein], and ultrasound examinations. RA patients were divided into two subgroups according to their DAS28-ESR; group 1 (DAS-28<3.2), group 2 (DAS28≥3.2), respectively. Forty-four healthy controls were simultaneously studied. Results: The serum PAPP-A levels of the RA patients were significantly higher than those of healthy controls (0.53±0.17 mIU/L, 0.43±0.15 mIU/L, respectively; p=0.003). Distribution of age and gender between these groups were similar. We found no statistically significant difference between group 1 (n=26) and group 2 (n=29) in PAPP-A levels, 0.53±0.16 and 0.52±0.17 respectively. p=0.88. And also, the data showed no statistically significant relationship between serum PAPP-A levels and disease activity parameters. Conclusion: In conclusion, PAPP-A levels were higher in patients with RA in comparison to controls, but there was no significant correlation with disease activity. Pathophysiological pathways of increased PAPP-A in RA are unclear. Further studies are required to better elucidate the role of PAPP-A level in RA, especially in patients who have concomitant CAD.