Some new bi- and ter-benzimidazole derivatives as topoisomerase I inhibitors

Alper S., ARPACI Ö., Şener Aki E., Yalçin I.

Farmaco, cilt.58, sa.7, ss.497-507, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 7
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0014-827x(03)00042-9
  • Dergi Adı: Farmaco
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.497-507
  • Anahtar Kelimeler: Benzimidazoles, Inhibitors, Topoisomerase I
  • Ankara Üniversitesi Adresli: Evet

Özet

The discovery of DNA topoisomerases has added a new dimension to the study of anticancer drugs. In the last years detailed investigation of bi- and ter-benzimidazole derivatives revealed that these compounds are a new class of topoisomerase I inhibitors that poisons mammalian topoisomerase I. In this context a survey about topoisomerase I poisoning activity and cytotoxicity of bi- and ter-benzimidazoles is given. Moreover some recent results about new derivatives, some structure-activity relationships and comparison of activity of various functional groups are discussed. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.