Syntheses of novel indole lipoic acid derivatives and their antioxidant effects on lipid peroxidation

Gurkan A. S., Karabay A. Z., Buyukbingol Z., Adejare A., Buyukbingol E.

ARCHIV DER PHARMAZIE, sa.2-3, ss.67-73, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1002/ardp.200400932
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.67-73
  • Anahtar Kelimeler: alpha-lipoic acid, indole, lipid peroxidation, antioxidant, MELATONIN RECEPTOR, SYSTEM
  • Ankara Üniversitesi Adresli: Evet

Özet

The aim of the study was to examine antioxidant properties of conjugates based on indole and lipoic acid moieties. The design and syntheses of novel indole alpha-lipoic acid derivatives were performed. The antioxidant properties of target compounds were investigated using rat liver microsomal, NADPH-dependent lipid peroxidation inhibition. Some of the target compounds, especially those containing amide linker at position 5 of indole ring, proved to be highly effective in inhibiting lipid peroxidation as compared to alpha-lipoic acid.