Synthesis and antidiabetic activity of 2,4-thiazolidindione, imidazolidinedione and 2-thioxo-imidazolidine-4-one derivatives bearing 6-methyl chromonyl pharmacophore

ÜNLÜSOY M., KAZAK C., Bayro O., Verspohl E. J., Ertan R., BOZDAĞ DÜNDAR O.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.28, sa.6, ss.1205-1210, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/14756366.2012.723207
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1205-1210
  • Anahtar Kelimeler: Antidiabetic drugs, 2,4-thiazolidinediones, imidazolidine-2,4-diones, 2-thioxo-imidazolidine-4-ones, chromonyl-2,4-thiazolidinediones, insulinotropic activity, HYPOGLYCEMIC ACTIVITY, FLAVONE DERIVATIVES, THIAZOLIDINEDIONES, COMMUNICATION, CHROMONYL-2,4-THIAZOLIDINEDIONES, THERAPY
  • Ankara Üniversitesi Adresli: Evet

Özet

Numerous compounds have been prepared in order to improve the pharmacological profile of insulinotropic activities. In the present paper, we report the synthesis and the in vitro insulin releasing activity of the 6-methyl-chromonyl-2,4-thiazolidinediones (IIIa-c, IVa-c, Va-c). Compounds IIIb, IIIc, IVa-c, Va and Vc (at lower concentration; 0.001 mg/mL) were able to increase insulin release in the presence of 5.6 mmol/L glucose. In this series, the most potent compound is IVa having methyl group at N3 position of TZD ring.