Translocation (13;17)(q14;q25) as a novel chromosomal abnormality in acute myeloid leukemia-M4

Turhan N., KUTLAY N., Topcuoglu P., Saykl M., YÜKSEL M., GÜRMAN G., ...Daha Fazla

LEUKEMIA RESEARCH, cilt.30, sa.7, ss.903-905, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 7
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.leukres.2005.12.011
  • Dergi Adı: LEUKEMIA RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.903-905
  • Anahtar Kelimeler: t(13;17)(q14;q25), AML-M4, poor prognosis, ALVEOLAR RHABDOMYOSARCOMA, MLL GENE, FUSION, T(11/17)(Q23,Q25), TRANSFORMATION, TUMOR, MSF, M2
  • Ankara Üniversitesi Adresli: Evet

Özet

We report a case of AML-M4 in which G-band karyotyping revealed a previously unreported t(13;17)(q14;q25) in metaphase preparations. The breakpoints at 13q14 and 17q25 are associated with poor prognosis. The MSF and FKHR genes are located on 17q25 and 13q14, respectively. This report of AML-M4 harboring t(13;17)(q14;q25) as a unique cytogenetic abnormality provides more data on the leukomogenesis with rearrangements related with 13q14 and 17q25. (c) 2005 Elsevier Ltd. All rights reserved.