Determination of ornidazole in pharmaceutical dosage forms based on reduction at an activated glassy carbon electrode

Ozkan S. A., Senturk Z., Biryol I.

International Journal of Pharmaceutics, cilt.157, sa.2, ss.137-144, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 157 Sayı: 2
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1016/s0378-5173(97)00208-1
  • Dergi Adı: International Journal of Pharmaceutics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.137-144
  • Anahtar Kelimeler: ornidazole, determination, voltammetry, activated glassy carbon electrode, GOLD ELECTRODE, NITROBENZENE, NITROSOBENZENE, MECHANISM
  • Ankara Üniversitesi Adresli: Evet

Özet

The electrochemical reduction of ornidazole was studied at a glassy carbon electrode activated by applying a new pretreatment. The dependence of intensities of currents and potentials on pH, concentration, scan rate, nature of the solvent (aqueous media, mixed aqueous-organic systems) and surfactant was investigated. Linear calibration plots were obtained over the concentration ranges 4 x 10-6-6 x 10-4 and 6 x 10-6-6 x 10-4 mol l- 1 in 0.2 M H2SO4 and acetate buffer (pH 4.7), respectively. The method was applied to the determination of ornidazole indifferent drug formulations.